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AUTHOR:
Dr Jacek Nowak, PhD
dentist, aesthetic medicine doctor
Autologous therapies have been gaining increasing popularity in recent years among patients who value natural treatment outcomes and consciously choose tissue regeneration and anti-aging approaches. Additionally, some patients with contraindications to traditional fillers – therefore disqualified from most hyaluronic acid–based procedures – may find an opportunity to improve their appearance through autologous therapies.
What are autologous therapies?
These are all procedures that use the patient’s own tissue, properly collected and processed, as the treatment material. They include both treatments using centrifuged blood – such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), autologous fillers – as well as fat grafting.
What is an autologous filler?
An autologous filler is a gel-like preparation obtained through the thermal processing of platelet-rich plasma, and more commonly כיום, platelet-rich fibrin (PRF).
Platelet-rich fibrin derived from the patient’s centrifuged blood is heated to 80°C and, after a change in consistency, cooled down. This process is carried out using a dedicated device such as the Autologic Plasma Maker.
Using platelet-rich fibrin as a base for creating a natural filler allows for better outcomes compared to platelet-rich plasma. This is due to the higher concentration of platelets containing growth factors.
Although thermal processing leads to protein denaturation, adding the liquid fraction of fibrin to the autologous filler immediately before injection results in a hybrid material.
What makes this material unique?
It consists of two key components:
- PRF-derived gel – provides a volumizing effect, enhances tissue volume and contour, and through mechanical stimulation of tissues increases the production of natural hyaluronic acid. It also stimulates fibroblasts to produce collagen and elastin.
- Liquid platelet-rich fibrin – rich in growth factors, offering strong regenerative effects. These factors influence undifferentiated stem cells from adipose tissue and dermal fibroblasts, enhancing neovascularization and neocollagenesis.
How long do the effects last?
The longevity of results varies depending on the patient, but studies indicate a duration of approximately 3 to 6 months.
After 3 months, the volumetric effect is typically maintained at about 60–70% of the initial volume, with a noticeable improvement in skin quality and texture.
To maintain results, the treatment should be repeated – typically 2–3 sessions per year are recommended.
What are the possible side effects?
As with any needle- or cannula-based procedure, possible side effects include:
- swelling
- pain
- redness
- bruising
These effects are usually short-lived and related more to the injection technique than to the product itself. Since the material is derived from the patient’s own blood, the procedure is considered immunologically safe.
Results of treatments using Skin Up Premium:
