Autologous
exosomes
AutologIX
AutologIX is a protocol for obtaining a concentrate of autologous exosomes from platelet-rich plasma (PRP) derived from the patient's own blood. This is made possible by a ready-to-use system composed of the ProtSmart6 ultraconcentrator and PRP tubes (with gel). Two key medical devices are involved:
PROTSMART6
Class IIa Medical Device – a selective exosome concentrator utilizing innovative ultrafiltration technology with specialized filters. The permeability is approximately ⏈15,000 kDa, with a perfusion diameter of <5 nm. Water and ion fragments are expelled into the collection bag, while exosomes, proteins, and cells are retained within the filter featuring a specialized membrane. Its high filtration capacity results from its unique structure, with the inner wall characterized by a high density of small pores.
PRP1 TUBES
Four Class IIA medical-grade tubes PRP with gel – a medical device designed for the preparation of autologous platelet-rich plasma (PRP) concentrate from the patient’s blood. During centrifugation, vesicles are released and remain suspended in the plasma. You can also safely use AutologIX with your existing 10 ml gel-based tubes and your current centrifuge. No additional tube handling or preparation steps are require.
The set also includes:
– A butterfly needle with holder
– 2 x 20 ml syringes
The system retains and concentrates exosomes, growth factors (PDGF, TGF-β, VEGF, FGF), cytokines, plasma proteins, platelets, and fibrin. Its methodology complies with MISEV2023 guidelines, and a comprehensive evaluation conducted by HansaBioMed Life Sciences confirmed: biomarker validation (presence of CD9, CD63, CD81, TSG101, and Alix), exosome purity and functionality, enhanced yield through mechanical activation, and proven therapeutic efficacy.
What are exosomes and how do they work?
Autologous exosomes are used in various fields of medicine, including orthopaedics, dermatology, pain management, wound healing, hair loss therapy, and rejuvenation treatments. What gives them their regenerative and reparative properties? It's worth knowing!
Exosomes are...
Extracellular vesicles (EVs) surrounded by a phospholipid bilayer, released into the extracellular space. They carry nucleic acids, proteins, and lipids from the cells they originate from. Exosomes deliver this cargo to recipient cells, acting as mediators of intercellular communication in both physiological and pathological conditions. They also serve as vehicles for transporting genetic material between cells.
They have the ability to...
Transmit critical intercellular information. During inflammation, they stimulate the immune response and exhibit antibacterial activity. It is also known that once absorbed by stem cells, exosomes release their contents into the cells, significantly influencing the metabolic dynamics of stem cells and enhancing their regenerative potential.
AutologIX is a protocol for obtaining a concentrate of autologous exosomes from the patient’s platelet-rich plasma (PRP), which is then administered into the skin via mesotherapy.
Indications:
- Skin rejuvenation with improvement in tone, texture, elasticity, and uniformity of the dermal layer
- Reduction of wrinkles and filling of fine lines
- Revitalisation of the eye contour
- Rejuvenation of the skin on the hands, face, and neck
- Accelerated healing of the skin following more invasive procedures, e.g. surgery
- Treatment of hair loss – including alopecia areata and androgenetic alopecia, as well as support during hair transplantation
- Reduction of inflammation
Exos on the metabolism of local cells (including MSCs and ASCs). The procedure is repeated no sooner than approximately 9 to 16 months later! In hair loss therapy, only two sessions are performed, spaced 2–3 weeks apart.
